Gait & Posture
Volume 26, Issue 2 , Pages 200-207, July 2007

Long-term monitoring of gait in Parkinson's disease

  • Steven T. Moore

      Affiliations

    • Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • Corresponding Author InformationCorresponding author at: Mount Sinai School of Medicine, Department of Neurology, Box 1135, 1 E 100th Street, New York, NY 10029, USA. Tel.: +1 212 241 9306; fax: +1 212 831 1610.
    • ,
  • Hamish G. MacDougall

      Affiliations

    • Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Jean-Michel Gracies

      Affiliations

    • Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    • ,
  • Helen S. Cohen

      Affiliations

    • Bobby R. Alford Department of Otolaryngology—Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA
    • ,
  • William G. Ondo

      Affiliations

    • Department of Neurology, Baylor College of Medicine, Houston, TX, USA

Received 4 May 2006; received in revised form 21 July 2006; accepted 8 September 2006. published online 17 October 2006.

Abstract 

A new system for long-term monitoring of gait in Parkinson's disease (PD) has been developed and validated. The characteristics of every stride taken over 10-h epochs were acquired using a lightweight ankle-mounted sensor array that transmitted data wirelessly to a small pocket PC at a rate of 100Hz. Stride was calculated from the vertical linear acceleration and pitch angular velocity of the leg with an accuracy of 5cm. Results from PD patients (5) demonstrate the effectiveness of long-term monitoring of gait in a natural environment. The small, variable stride length characteristic of Parkinsonian gait, and fluctuations of efficacy associated with levodopa therapy, such as delayed onset, wearing off, and the ‘off/on’ effect, could reliably be detected from long-term changes in stride length.

Keywords: Stride length, Levodopa, Parkinsonian, Locomotion, Accelerometer

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PII: S0966-6362(06)00190-1

doi:10.1016/j.gaitpost.2006.09.011

Gait & Posture
Volume 26, Issue 2 , Pages 200-207, July 2007

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